Cerenity PM is a comprehensive formulation created for patients experiencing occasional sleeplessness. Cerenity PM promotes a healthy sleep cycle by naturally boosting levels of serotonin, GABA and melatonin using bioactive cofactors and amino acids; phosphatidylserine is also included as a vital ingredient for those with elevated evening cortisol levels that may be contributing to frequent waking.
L-tryptophan is converted into the amino acid intermediate 5-hydroxytryptophan (5-HTP), which is then converted directly into serotonin, followed by melatonin conversion. Clinical studies have demonstrated the ability of 5-HTP to promote and enhance sleep. 5-HTP increases REM sleep by about 25%, while increasing deep sleep stages 3 and 4, without lengthening total sleep time. Non-REM stages 1 and 2, the least important stages, are reduced to compensate for this increase, resulting in an increase in sleep efficiency.
Gamma-amino butyric acid (GABA) is one of the major inhibitory neurotransmitters in the brain. GABA provides a calming effect and plays a direct role in activating the sleep cycle in the evening. Cerenity PM includes a patented, naturally-sourced, non-synthetic form of GABA called PharmaGABA™. In a study utilizing 100 mg of PharmaGABA™, supplemented before bedtime, PharmaGABA™ was shown to reduce sleep latency by 20%, while increasing time spent in a deep sleep by 20%. PharmaGABA™has also been shown by electroencephalogram (EEG) readings to increase the ratio of alpha to beta waves in the brain resulting in a calm and effortless state of relaxation.
Phosphatidylserine (PS) is a phospholipid found in high concentrations in the brain. Phosphatidylserine has been shown to play a role in regulating cortisol excretion. In studies administering PS (50-800 mg) to subjects under high levels of stress (physical and mental), PS was shown to reduce stress-induced secretion of cortisol, which is also crucial for reducing frequent waking.
Taurine is an amino acid that is found abundantly in the brain and has neuroprotective properties. Taurine promotes inhibitory neurotransmission by activating GABA receptors. Taurine also supports inhibitory neurotransmission by activating glycine receptors in the brain.
Calcium and magnesium are two minerals that play a major role in supporting a healthy sleep cycle. Magnesium calms the nervous system and has been shown to play a role in the regulation of the HPA axis. Calcium ions are a critical requirement in the synthesis of melatonin. The combination of 5-HTP and calcium in Cerenity PM provides a significant and natural boost to melatonin levels, aiding in the conversion and activation of this crucial sleep hormone.
Cerenity PM includes essential nutrients that are required cofactors for the synthesis of serotonin and GABA. This includes 5-methyltetrahydrofolate (5-MTHF), vitamin B6 (P-5-P), vitamin C, zinc and magnesium to enhance neurotransmitter synthesis.