Vinco's LadyBiotic® UTH, contains Cran-Gyn® DDS®, which is a patent-pending triple action formula that contains DDS® Probiotics, Cranberry Juice Extract, and natural D-Mannose. LadyBiotic® UTH is specifically formulated to address unique feminine considerations including urinary tract health, digestive health, immune function, and yeast management. No Wheat, Eggs, Yeast, Corn, Soy, Gluten, Artificial Colors or Preservatives. NON-GMO and Vegan Laboratory tested to meet strict quality control.
Supplement Facts: Serving Size: 2 Vegetarian Capsules, Servings per Container: 30
Amount per Serving %DV
A proprietary blend containing (1g) †
Cranberry Juice Concentrate,
Lactobacillus acidophilus DDS-1®,
which provide: 5 Billion CFU (Colony Forming Units)
* Daily Value (DV) not established
DV is based on a 2,000 calorie diet
Other Ingredients: Vegetable Cellulose, Rice Maltodextrin, Vegetable Magnesium Stearate, Magnesium Hydroxide, Tricalcium Phosphate
Vinco’s LadyBiotic® UTH is formulated to address the unique health needs of women. LadyBiotic® UTH targets urinary tract health, digestive health, immune function and management of healthy yeast levels.
Urinary Tract Infections
Urinary tract infections (UTI) are particularly prevalent in women with over 50% of women reporting UTIs at some time in their life and over 30% suffering from recurrent problems. UTIs result in over 10 million doctor visits per year at a cost of over $3.5 billion. It is estimated that over 11 million women with UTIs in the US will be treated with antibiotics. Antibiotic treatment can often result in a secondary yeast infection that requires anti-fungal treatment. The primary cause of lower urinary tract infections is a common fecal bacteria, E. coli. (Approx 90% of cases).
UTIs occur when the bacteria enter the urethra and bladder causing infection, severe irritation and inflammation. In the past ten years, there have been many studies that demonstrate that lectins on the bacterial surfaces may be involved in starting the infection by assisting in bacterial adherence to epithelial cells. Bacterial adherence appears to be one of the prerequisites for the development of UTIs.
Probiotics - Broad Spectrum Application For UTI
Studies indicate that women with no history of UTI have high numbers of Lactobacilli present in the urogenital area and that patients with a history of recurrent UTIs have severely depleted numbers of Lactobacilli. Researchers indicate that the Lactobacilli provide a bacterial barrier able to interfere with the ability of pathogens to colonize the vagina and reduce the risk of ascension into the bladder.
In a study on prevention of UTI, a weekly vaginal suppository containing L. rhamnosus GR-1 and L. fermentum B-54 for one year showed significant reduction in UTI during the Lactobacillus use (from 6 times per year to <1.6 times per year). A pilot study using vaginal suppositories of hydrogen-peroxide producing Lactobacillus crispatus demonstrated reduction in UTI recurrence. Lactobacilli and the hydrogen peroxide they produce are emerging as essential components of a healthy microflora environment. Hydrogen peroxide is toxic to many microorganisms at concentrations that are typical in vaginal fluid and thus provide intrinsic protective mechanism in the vagina.
Another possible mechanism of action involves production of bacteriocins by Lactobacilli. Lactobacillus acidophilus DDS®-1 produces a natural antibacterial substance called acidophilin that has demonstrated activity against several strains of bacteria including E. coli. In a case study of L. acidophilus DDS®-1 with two billion viable organisms, there were positive results in prevention of recurrent UTIs.
Irritable Bowel Syndrome
One of the most prevalent digestive conditions affecting both men and women, but significantly more women, is irritable bowel syndrome (IBS). It affects over 20% of the population in Western countries with a female to male ratio of 2-2.5:1. IBS remains to be a clinically defined illness and traditionally, is a diagnosis of exclusion. Although many pathophysiologic factors have been implicated in IBS, recently, researchers have considered food intolerance imbalance of the intestinal microflora and colonic malfermentation as potential factors responsible for IBS. Current treatment options for IBS are thought of as unsatisfactory, and probiotics are on promising therapeutic option.
A promising application is to use probiotic bacteria that interact with the host epithelium to resolve inflammation and preserve barrier function. Currently
most commonly studied probiotics are lactic acid bacteria (LAB). Some probiotics including Bifidobacterium and Lactobacillus species have been shown to relieve symptoms.
Recently, researchers conducted a multi-patient case study using a probiotic blend (Multi-Flora Plus) containing L. acidophilus DDS-1, B. longum, B.
bifidum, and B. lactis at a potency of 12 billion CFU/g. After treating 25 patients for 8 weeks, the researchers demonstrated a significant decrease in symptom severity
Bacterial Vaginosis (BV) and Vulvovaginal Candidiasis (VVC)
BV and VVC are the most prevalent vaginal infections worldwide. BV causes up to 50% of vaginal infections and is accompanied by a significant reduction in lactobacilli.
VVC affects up to 75% of women at least once in their lives. The total annual cost (in 1995) for dealing with VVC was estimated at $1.8 billion. Although the pathogenesis of VVC remains controversial, it seems that the balance between the microorganisms in the vaginal microbiota is a factor that influences overgrowth of Candida. Antibiotic therapy, spermicide use, oral contraceptives, estrogen therapy, diabetes, tight clothing and frequent sexual intercourse are all factors that increase the risk of development of VVC.
Lactobacilli modulate the vaginal microbiota by different mechanisms such as: (1)augo-aggregation, (2)production of lactic acid, hydrogen peroxide, bacteriocins, biosurfactants, (3)co-aggregation with pathogenic microorganisms and (4)adhesion to epithelial cells.
Probiotics - Broad Spectrum Application For Bacterial Vaginosis (BV)
In BV, anaerobic bacteria multiply in large numbers and form biofilms on the epithelium which results in elevated pH and production of sialidase, hemolysins and factors that induce inflammatory cytokines. One trial of 64
women taking oral Lactobacilli led to a significant reduction of uropathogens and yeast in the vagina. Hydrogen peroxide producing Lactobacilli are believed to be important in conferring protection. A study of 290 subjects showed that females colonized by H2O2 producing Lactobacilli, vaginally and rectally, had a reduced risk of vaginal infection. Lactobacillus DDS®-1 produces hydrogen peroxide in addition to a potent bacteriocin.
Probiotics - Broad Spectrum Application For Vulvovaginal Candidiasis (VVC)
Lactobacilli exert a protective effect against VVC by several mechanisms. The first is adherence to the vaginal epithelium leading to intensive surface colonization and biofilm formation. The subsequent production of active metabolites including acidic products, bacteriocins and hydrogen peroxide further inhibit the growth of Candida. The third mechanism involves co-aggregation of Lactobacillus and Candida which creates a microenvironment around the pathogen with a higher concentration of inhibitory substances and blocking the dissemination of pathogens to tissue receptors.
Cranberry Extract and UTI’s
Both in vitro and in vivo tests using cranberry for UTI in animals has been effective. It seems that cranberry inhibits the adhesion of type 1 and P-fimbriated uropathogenic E. coli to the uroepithelium, preventing colonization and subsequent infection. E. coli with type 1 fimbriae are mannose sensitive and P-fimbriated E. coli are mannose resistant. The specific components of this anti-adhesion quality have been difficult to identify but there is emerging evidence that the anthocyanidin / proanthocyanidin fractions are involved since they have strong anti-adhesion properties.
Many studies have been conducted using cranberry to prevent recurrence of UTIs. In one meta-analysis, the recurrences were reduced by approximately 35%. There appears to be little difference whether the cranberry is in juice or tablet form.
Mannose Therapy and UTI’s
Tamm-Horsfall Protein (THP) is a mucoprotein found in the urinary tract. It is the most abundant protein involved in innate urinary defense. THP deficiency
predisposes individuals to bladder infection by type 1- fimbriated E. coli. Deficiency in THP does not enhance the ability of P-fimbriated E. coli to colonize the bladder. New studies show that mannose can bond to THP and serve as a receptor to type 1-fimbriated E. coli thus preventing them from adhering to uroplakin receptors on the uroepithelial surface. The ability of D-Mannose to inhibit type-1 fimbriated E. coli is the foundation for its use by sufferers of UTI infection.
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