Zygest 180 Capsules (Vegetarian) For Proper Digestion PhysioLogics

Zygest 180 Capsules (Vegetarian) For Proper Digestion PhysioLogics
Item# PL-055121

PRODUCT IS A SYNERGISTIC MIXTURE OF Bromelain (from Pineapple), Papain (from Papaya Fruit), Protease 3.0 (from Aspergillus niger), Amylase (from Aspergillus oryzae), Lipase (from Aspergillus niger), Protease 4.5 (Aspergillus oryzae), Lactase (from Aspergillus oryzae), Cellulase (from Trichoderma longibrachiatum), Hemicellulase (from Aspergillus niger)

PRODUCT DISCUSSION ZygestŪ is a registered dietary supplement with the United States Patent and Trademark office. This specialized formulation contains a broad spectrum of protein, carbohydrate, and fat-digesting enzymes to promote digestion of nutrients. ZygestŪ is designed to offer support at various levels including digestion occurring in the fundus and antrum of the gastric region, as well as digestion taking place in the duodenum and other areas of the small intestine. Enzymes are formulated to reflect activity levels as certified by a Quality Control specialist, utilizing standards set through the Food and Chemical Codex (FCC).*

STRUCTURE AND FUNCTION ZygestŪ contains multiple enzymes designed to serve as biological catalysts for the breakdown of macronutrients.*

Amylase is an enzyme that is naturally secreted by pancreatic cells in-vivo. Release of this enzyme is stimulated by carbohydrate containing foods. Once released, amylase can biochemically react with digestion products such as starches and glycogen to form di- and trisaccharides through hydrolysis. The amylase within ZygestŪ is certified in dextrinizing units, which is defined as the quantity of alpha-amylase that will dextrinize soluble starch in the presence of excess beta-amylase.*

Protease is an enzyme designed to assist in protein digestion. Protein digestion begins in the gastric region when splitting occurs at nitrogen bonds to form products such as proteoses, peptones, and large polypeptides. Digestion continues with pancreatic enzymes of the upper small intestine and with the epithelial cells of the small intestinal wall. ZygestŪ contains Proteases standardized through both Hemoglobin Unit of Tyrosine Basis (HUT's) and Spectrophotometric Acid Protease Units (SAPU's), two different measures of protein digestion.*

Lipase is another naturally occurring enzyme which helps digest fat, and can be found in-vivo in the pancreas and epithelial cells of the small intestine. Fat digestion is a multi-level process which includes emulsification to decrease the interfacial tension of the fat globule surface. Once this is achieved, enzymes such as lipase can then help split fat into monoglycerides and fatty acids. ZygestŪ contains Lipase which is certified through Lipase Units, which is based on digestion of a standard olive oil substrate.*

Lactase is a specialized enzyme designed to split lactose disaccharides into glucose and galactose monosaccharides. Lactase is naturally found in the microvilli of the brush border of the epithelial cells. Once lactose digestion occurs, glucose and galactose are immediately absorbed into the portal blood. The lactase in ZygestŪ is certified through Acid Lactase Units (ALU's), which is a measure of its ability to liberate o-nitrophenol per conditions of the assay.*

Both Bromelain and Papain are added for their protein digestibility scores. Each is certified through Papain Units as defined by the FCC. Papain Units measure tyrosine liberation per hour under the specific conditions of the assay.*

Cellulase and Hemicellulase round out the ZygestŪ formula. Cellulase is certified through Cellulase Units, which measure the quantity of enzyme required to produce a relative fluidity change of 1 in 5 minutes of a standard cellulose solution. Hemicellulase is certified through Hemicellulase Units per FCC regulations, which is the amount of enzyme required that will produce a relative fluidity change of 1 over a period of 5 minutes in a locust bean gum substrate under specific assay conditions.*

INDICATIONS For clients seeking a premier digestive enzyme supplement that contains a broad-spectrum of enzymes and activity, ZygestŪ is an excellent choice.* ZygestŪ can be orally administered regardless of the meal composition or nutritional plan, due to its diverse enzyme preparation.


* Utilizing a form of digestive enzymes studied in scientific gastrointestinal models and certified through FCC standards.* * Formulated to provide gastric support for all types of nutritional plans, whether they are low or high carbohydrate, fat and protein.* * Multi-level support by supplying 10 distinct digestive enzymes.* * All enzymes formulated from vegetarian sources.* A second digestion study was conducted by the same research group, this time using a model that simulated conditions when digestion would be significantly reduced. Results found that adding digestive enzymes promoted digestion of carbohydrates and proteins compared to digestion without enzymes. These results were obtained through samples taken at the level of the jejunum and ileum. Based on the results of both studies, the researchers concluded that enzymes from the National Enzyme Company (suppliers of ZygestŪ) can be used to support digestion.

CLINICAL EVIDENCE A digestion study was conducted by The Netherlands Organisation for Applied Scientific Research. The experimental protocol was conducted with a computer controlled dynamic gastrointestinal model (TIM). TIM is a patented technology designed to stimulate the conditions of the human stomach and small intestine and allows for sampling at various stages to obtain real time data. Results found that adding digestive enzymes, as found in ZygestŪ, promoted digestion of carbohydrates as compared to digestion without additional digestive enzymes. Results also found that digestion of proteins in the ileum was positively supported as compared to digestion without added enzymes.

SUMMARY ZygestŪ is a specialized blend of digestive enzymes that can be easily incorporated into multiple types of nutritional plans. The enzyme blend is processed through the National Enzyme Company, which is the leader in nutritional enzyme technology. All the digestive enzymes are labeled according to activity units as opposed to mg amounts, and are certified by a Quality Control specialist based on the regulations set forth in the Food and Chemical Codex.*

SUGGESTED DOSAGE Take one (1) to two (2) capsules up to three times daily with meals or follow the advice of your health care professional. As a reminder, discuss the supplements and medications you take with your health care providers.

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Eckert, K., et al. Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary patients. Oncol Rep. 1999. 6(6); Nov/Dec: 1191-1199.

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Minekus, M. et al. A multi compartmental dynamic computercontrolled model simulating the stomach and small intestine. Alternatives to Laboratory Animals. 1995. 23:197-209.

Minekus, M. In vitro model of an in vivo digestive tract. US Patent 5,525,305. 1996.

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Zeijdner, E. The fate of orally administrated compounds during passage through the GI tract simulated in a dynamic in vitro model (TIM). European pharmaceutical Contractor. Feb. 76-81.

Zeijnder, E. et al. Latest tool for screening new clinical foods. A dynamic, computer-controlled model of the human gastrointestinal tract is the most up to date technology for testing new foods. New World Health. 1999/2000. 105.a Vegetarian Formula = Vegetarian Formula